Alzheimer's disease is thought to occur when amyloid β protein accumulates in the brain, causing damage to the cranial nerves. It is difficult to accurately measure very small concentrations, about 1/50 of the cerebrospinal fluid, and blood Aβ with conventional techniques, and amyloid β begins to accumulate in the brain about 20 years before the onset of impossibility. It seems. Therefore, it is important to notice and prevent at the stage of Mild Cognitive Impairment and Subjective Cognitive Decline. One of the causative factors of Alzheimer's disease in collaboration with the National Research and Development Corporation, Industrial Technology Research Institute, Biomedical Research Division, Brain Genetics Research Group, Hokkaido University Graduate School of Advanced Life Sciences, and Juntendo University School of Medicine, Department of Neurology. Developed a technology to visualize the dynamics of a certain amyloid β (Aβ) protein in living nerve cells and in vivo. This technology is expected to contribute to the screening of candidate substances for Alzheimer's disease therapeutic agents using cultured cells and living individuals, and to the elucidation of the onset mechanism of Alzheimer's disease. Details of this achievement were published in Scientific Reports (Sci. Rep. Nature Research) magazine (electronic version, open access) on March 16, 2016. Aβ polymerizes easily, and it further aggregates to form large aggregates. It seems that the protein (Aβ-GFP), which is a fusion of Aβ and the fluorescent protein GFP, is presumed to inhibit the fluorescence of GFP by the polymerization of Aβ. Therefore, even if it is expressed in vivo, fluorescence is not observed when Aβ is polymerized, and it seems that it has been difficult to visualize the localization and dynamics of Aβ so far. Amino acid sequence linking Aβ and GFP (human insulin: In 1953, British chemist Frederick Sanger gave the 51 amino acid sequence of insulin (a hormone required for the use of glucose, etc.), which is a hormone secreted from the bovine pancreas. Prove by determination. Start with the short-chain primer binding next to the measurement region. In the presence of four types of nucleotides, the polymerase enzyme binds the complementary nucleotides of the template DNA to the primer and extends. The intention to determine the exact DNA sequence is to stop this reaction prematurely and identify the last base at which extension has stopped, but Frederick Sanger removes the oxygen atom from the ribonucleotide to cause the extension reaction. This is called a dideoxynucleotide, and when it is taken in instead of a ribonucleotide, it seems to act to stop the elongation reaction, as if throwing a wrench into a gear to stop the movement. Polymerizer (The information of the protein written in DNA is once transcribed into mRNA and then translated into amino acids by ribosome to form a protein. RNA polymerase is used to transfer DNA to mRNA. Gene DNA is used as a template for RNA. The four nucleosides (A: adenosine, U: uridine, G: guanosine, C: citidine) that form the basis of the amino acid are polymerized to synthesize mRNA.) The enzyme will not be able to add normal nucleotides to the DNA fragment in the future. In order to stop the elongation reaction and identify what the last base is, it seems that the dideoxynucleotides are labeled with a specific color of 4 for each base so that they can be identified. In the Frederick Sanger sequence, the 3'end. By devising a reaction product of various lengths that differs by one base, which ends with dideoxynucleotide, we have developed a fusion protein that allows observation of GFP fluorescence regardless of the polymerization state of Aβ. It also appears that this fusion protein forms a highly toxic Aβ oligomer that is involved in the development of Alzheimer's disease. Diagnostic imaging methods such as PIB-PET (PET examination using PIB (Pittsburgh compound-B) as a ligand that can image amyloid accumulated in the brain) are effective, but Aβ oligomers and tau oligomers should be targeted. It seems that it is not an amyloid plaque or a neurofibrillary tangle. In addition, Alzheimer's disease is said to be the most common type of dementia, and I hear that it is more common in women than in men. In addition, while the number of patients with cerebrovascular dementia is flat, it seems that there is a tendency for it to increase. Dementia is thought to occur when the neural network of the brain is destroyed. Nerve networks consist of nerve cells exchanging information via neurotransmitters, and the junction between nerve cells where this information is exchanged is called a synapse. Impaired work seems to affect learning and memory. When not only the synaptic site but also the nerve cells themselves are damaged, causing cell death and starting to drop out, it seems that they become aware of forgetfulness (mild cognitive impairment). Eventually, when so many nerve cells are lost that the brain atrophies, it interferes with normal life and is diagnosed with dementia. In other words, many nerve cells have already died by the time dementia is diagnosed. And the dead nerve cells do not return to their original state and become the glory of the past. It is important to detect abnormalities before nerve cells begin to die and to start preventive treatment at an early stage.

【Product name】

Greenhouse Citrus reticulata Siranui

【Type】

Citrus unshiu × reticulata ‘Siranui’

【Producing area】

Fukae Town, Minamishimabara City, Nagasaki Prefecture (Zennoh Nagasaki)

【Origin of the name】

‘Shiranui’ - Shiranuhi Town, Uki City, Kumamoto Prefecture is said to be the birthplace. It was probably named after the place name. Dekopon（Citrus reticulata Siranui）is a registered trademark owned by the Kumamoto Prefecture Fruit Agricultural Cooperative Association. Under the umbrella of the japan horticultural agricultural cooperative association: Shipped through an agricultural cooperative association with JA and citrus production. Only those who meet certain standards to maintain high quality can use the name. It was shipped through the National Federation of Citrus Agricultural Cooperatives with a sugar content of 13 degrees or more and an acidity of 1 degree or less. 

【Major features】

February 1, 2022 A total of 16 land improvement districts in Minamishimabara City, Nagasaki Prefecture merged to form the Minamishimabara Land Improvement Zone. With a total area of ​​932 hectares and 2163 union members (as of April 1, 2020), it is the largest in the prefecture. It seems that they will improve their constitution to respond to changes in agriculture by improving work efficiency and reducing costs. On February 1, the first board meeting was held, and Mr. Shiki (former chairman of the Onoue Polder Zone) was appointed as the chairman. The land improvement district is a farmer's union organization based on the Land Improvement Act (Land Improvement Act (1949 Act No. 195) Enforcement Date: April 1, 2020 (according to 2018 Act No. 12)). It seems that it will carry out farmland maintenance, new construction of drainage, maintenance, etc. Due to the merger, there are two land improvement districts in the city, “Minamishimahara Land Improvement Zone” and “Shimabara Fukae Land Improvement Zone” that straddles both Minamishimahara and Shimabara cities. On the same day, the ceremony to convey the merger permit was held at the Kitaarima Piloti Cultural Center Hinoe in Kitaarima Town, and it seems that 40 people concerned attended. The land improvement district is expected not only to improve the infrastructure of agricultural land, but also to take measures against villages. The prefecture, city, etc. will work together to provide support. Mr. Honda (former Chairman of the Arima Reclaimed Land Improvement Zone) decided to “proactively work on establishing an agricultural production base, appropriate maintenance of facilities, renewal projects, etc.” with “for union members” as the first priority. Seems to have been renewed. “Sezumezaki Lighthouse” in Minamishimabara City, Nagasaki Prefecture, located at the southernmost tip of the Shimabara Peninsula, which connects Minamishimabara City, Amakusa City, Kumamoto Prefecture, and Nagashima Town, Kagoshima Prefecture with two bridges. Amakusa Shimojima can be clearly seen beyond Hayasaki Seto, the distance is only about 5 km. Even after that, no concrete movements have been seen, and it seems that the interest of the residents is diminishing. Since the establishment of the council with the three prefectures of Kumamoto, Nagasaki, and Kagoshima at the local period association, etc., we have been making efforts toward realization. Although the investigation has been carried out concretely with an eye on it, the efforts of the domestic strait crossing project including this bridge concept have been frozen since 2008 due to the deterioration of the financial situation and the flow of review of large public projects. Under these circumstances, in Kumamoto, Nagasaki and Kagoshima prefectures, in order to increase the momentum for promoting construction, we will hold lectures on promoting the bridge concept, as well as exchange cooperation projects such as painting contests and soccer tournaments by elementary and junior high school students. (Confirmed that it will continue to be implemented by the three prefectures as a whole). Also, the secretariat of the “Shimabara / Amakusa / Nagashima Bridge Construction Promotion Council” organized by the three prefectures and local associations (Nagasaki Prefecture). (Inside the Community Development Promotion Division), “The severe situation has continued since the cross-strait project was frozen in 2008 due to the review of large-scale public projects in the country. , I want to promote active exchanges between regions and strive to foster momentum.” In addition, the annual estimated project cost of the council is about 4 million yen. We are trying to get excited through the youth soccer tournament and the painting contest, including the regional tournament that promises to realize this, but it seems that there are some events that have not been held recently due to the influence of the New Cov disaster. It is about 2 hours by car to Nagasaki city. The completion of the regional high-standard road “Shimabara Road” is still a long way off. It seems that there are many locals who think that the biggest obstacle to attracting companies and promoting industry and regions is the “road network”. In 2000, 57,000. The population of Minamishimabara City, which was a human, has decreased to about 43,500 as of December 2021. It seems that the population has decreased by more than 10,000 in the last 20 years. 15 to 64 years old) is on the decline.  It seems that the decline in regional vitality has also become noticeable. According to local residents, if the bridge is realized, it should be a detonator for the area. In particular, if a route to Kagoshima can be established, it will be a plus in terms of tourism. The local economy is also moisturized, and I hope that it will return to the time of the Corona disaster. Hope against hope: 一縷の望みを託す（A state where a very slight connection can be felt）to the chief and the country. Blessed with a warm climate, moderate rainfall and sunshine hours, it is famous as an area where agricultural products can be easily cultivated. Located in the southeastern part of the Shimabara Peninsula, in the southern part of Nagasaki Prefecture. It borders Shimabara City in the north and Unzen City in the west. Facing the Amakusa area of ​​Kumamoto prefecture across the Ariake Sea, I am deeply moved by the memories I visited once. It has a land containing fertile and abundant groundwater that extends south from the foot of Mt. Unzen, which exceeds 1,000 m. It also has a coastline that faces the Ariake Sea and Tachibana Bay, which are rich in seafood. Agriculture, forestry and fishing are carried out by the residents. Historically, there was a time when Christianity was introduced to this area in the 1560s and Christian culture prospered. The Edict expelling Jesuit missionaries was a prohibition document concerning the mission of Christianity and trade with Spain and Portugal issued by Hideyoshi TOYOTOMI in Chikuzen Hakozaki, in July 24, 1587 : There are many historical heritage sites in the city that show the light and shadow of Christianity in Japan. 1637: Shimabara-Amakusa Riot (Shimabara War): The Shimabara War broke out, lasting two years from 1637 to 1638. In such a situation, the occurrence of Shimabara / Amakusa uprisings led the bakufu to the complete prohibition of Christianity and the complete national isolation that allowed only bakufu-controlled trade. “Hara Castle Ruins” is “Hidden Christian-related heritage of Nagasaki and Amakusa Region” : Registered for UNESCO World Cultural Heritage on June 30, 2018. The shimabara peninsula area has been certified as the first in Japan by the global geopark networks, which is said to be the geological version of the world heritage（Unzen Volcanic Area Geopark: In 2009, with Itoigawa in Niigata and Mt. Toyakousu（Lake toya Mt. Usudake）in Hokkaido）. An area where you can feel the heartbeat of the earth and the history of the earth. “City designated cultural property”, Uchiishibashi group（Kitaarima Town）: It was built from the late Edo period to the early Showa period. About 10 arch bridges made of natural stones and cut stones are left in the Arima River system in Kitaarima Town. The construction of the arch bridge requires a high level of technology because the strength of the stones is maintained by the weight of the stones. Natural stones are used for most of the stone bridges such as wall stones. At first glance, it looks like a rough structure, but in reality, it requires more skill to combine stones that are not standard products. I hear that the biggest advantage is that it is relatively easy to procure materials. Since the bridge is also a part of the living road, it requires quick repair. It can be said that the skillful skills of the masons closely supported people's lives. The scenery where the stone bridge is in harmony with the river and fields is also beautiful. We will support the cultivation of ‘Bananas’, which are expected to be new high-profit and high-value-added crops. Liability Company（LLC.）, which develops business by utilizing subsidiary aid. We received 100 seedlings from company limited, an agricultural corporation that grows bananas in Kagoshima and Saga. ‘Freeze-thaw awakening method’ : By freezing and thawing growing cells for half a year and applying special treatment, resistance to cold and diseases becomes stronger. The Banana applied this time is pesticide-free and does not use pesticides or cleaning agents, so the skin is thin and the whole skin can be eaten. The sugar content is 25 degrees, which is much higher than the general 15 degrees, and is characterized by its rich sweetness and mellow aroma. About 150 trees can be harvested from one tree, and mature bananas are scheduled to be harvested around the summer of 2021. When it was transmitted, it was around last fall and before my favorite winter. ‘Arima Christian Heritage Museum’ - 南有馬町 - The background behind the 250 years of Christianity's hiding : The process leading to the suppression of Christianity, 1637 : Shimabara-Amakusa riot (Shimabara War) situation is displayed in an easy-to-understand manner. Hei, Minamiarima Town: Seibo Park is an art park that exhibited works in the birthplace of Seibo KITAMURA（Graduated from the sculpture department of Tokyo Fine Arts School (currently Tokyo University of the Arts: Masterpiece: Taisuke ITAGAKI old man (inside the Diet Building); Peace Memorial Statue (Nagasaki Peace Park)) in 1912. His career In 1908, “Indignation” was selected for the first time at the 2nd Art Exhibition (Bun Exhibition) of the Ministry of Education. He has been exhibiting every year since then, and the 10th “Evening Bell” will be the chief of choice. In 1919 he became a judge for the Japan Fine Arts Exhibition and formed the Hibarasha in the same year. He was a professor at Tokyo Beauty School from 1921 to 1944, and became a member of the Imperial Academy of Fine Arts in 1924 and a member of the Japan Art Academy in 1947. He specializes in heroic human figures, and before the war he worked on equestrian statues of military personnel and statues of great men. After the war, he became a central member of the Japan Fine Arts Exhibition sculpture department, focusing on peace and freedom. In 1951, he was requested by Nagasaki Prefecture to build an atomic bomb monument at the hypocenter of the atomic bombing, and in 1955 he completed the “Nagasaki Peace Memorial Statue”.）, a sculptor who was born in Minamiarima Town, Minamishimabara City and is famous for the creator of the Nagasaki Peace Memorial Statue. In the wooden memorial hall where the garden and the birthplace were restored, about 60 works such as “Peace Statue”, sculptors, books and paintings are exhibited, and you can see the condensed essence of Seibo art. It seems. Also, from the park with a good view overlooking Amakusa Nada, you can see the nationally designated historic site “Hara Castle Ruins” known for the Shimabara Rebellion. Fukae Buried Cultural Property / Eruption Disaster Museum (Bo, Fukae Town): Exhibits of excavated ruins (earthenware, etc.) and photographs of the Unzen Fugendake eruption disaster. Access is a 20-minute walk from the Shimabara Railway Bus “Front Monument” bus stop, in front of the Sabo Miraikan and the former Onokoba Elementary School damaged school building. The former Onokoba Elementary School disaster-stricken school building erosion control Mirai Hall, also located in Bo, Fukae Town, is a disaster prevention sabo learning facility that inherits the actual situation of volcanic disasters and is the core facility of the Ministry of Construction's utilization concept disaster memorial zone. The large pyroclastic flow that occurred at 18:54 on September 15, 1991 burned down the elementary school along with 153 building of nearby private houses. In the town, although evacuation was thorough and there was no human damage, it is preserved as one of the pyroclastic flow remains and sabo learning bases that inherit the wonder of this disaster and the wonder of natural disasters. There is also the Onokoba Sabo Miraikan, which is under the jurisdiction of the Ministry of Land, Infrastructure, Transport and Tourism, and it seems that you can observe the disaster situation and reconstruction through photographs and panels. Heisei Shinzan peaked at an altitude of 1488 m in June 2013 and has now shrunk slightly to 1482.7 m (the altitude of Heisei Shinzan measured by the National Land Research Institute in August 1996 was 1486 m, but after that. Due to the collapse, the current altitude of the mountaintop is 1483 m. It was designated as a nationally designated natural memorial on April 5, 2004). It is also the highest peak in Nagasaki Prefecture, and was born as part of Mt. Unzen, which consists of Mt. Since the appearance of the first lava dome on May 20, 1991, 13 lava domes have been born, and the dome has repeatedly collapsed several times as it grew, and the pyroclastic flow caused by the collapse killed precious lives. It has been. Three eruptions have been recorded at Unzen volcano. The oldest eruption was in 1663, the next in 1792, and the latest in 1990-1995. According to records, on the evening of May 21, 1792, Mt. Bizan, which rises to the west of Shimabara City, collapsed due to a large earthquake. The earth and sand flow into the Ariake Sea and cause a big tsunami: tidal wave. The damage extends not only to the Shimabara Peninsula but also to the Kumamoto side on the opposite bank, and has been the largest damage in the history of volcanic disasters in Japan since the dawn of history. Mt. Mayuyama, which rises to the west of Shimabara City, collapsed due to the large earthquakes that occurred frequently at the end of the eruption of Mt. Fugen in Unzen. It seems that the earth and sand became debris avalanche and not only filled the south side of the town of Shimabara at that time, but also plunged into the Ariake Sea at once and caused a big tsunami. This tsunami also rushed to Higo no Kuni (Kumamoto) on the opposite bank, causing enormous damage on both the Shimabara Peninsula and the Kumamoto side. The number of victims of this disaster has reached 15,000, making it the largest volcanic disaster in Japan since recorded history. From the observatory of Nita multi-unit apartments foremost Park in Shimabara City, you can observe the vivid collapsed wall of Mt. It can be observed below. It seems that the flowing mountain that flowed into the sea was named Tsukumojima. Shimabara Tadataka Ino surveyed 45 islands 20 years later (Ministry of Land, Infrastructure, Transport and Tourism Kyushu Regional Development Bureau Unzen Reconstruction Office 2007), but now the number has decreased to 17 due to erosion and submersion. As of 2022, the eruptive activity has subsided and the lava dome is part of Mt. Unzen, which has a magnificent landscape. Shimabara City, along with Obama Town（Unzen City）, named this dome part Heisei shinzan on May 20, 1996, the fifth year since the first lava dome appeared, and named it Heisei Shinzan for a long-lasting disaster and new reconstruction. It is a memorial. At the Nagasaki Agrinet Forum held in February 2016, the “Kuchinotsu Youth Farmers Liaison Council” won the highest award, and the “Fukae Town 4H Club” and “Kazusacho 4H Club” won the highest award. At the forum, the Kuchinotsu Youth Agricultural Liaison Council has announced how to effectively utilize under-managed bamboo grove. Members have a common sense of crisis in the region and recommend that efforts in a wide area are necessary. The Kuchinotsu Town Youth Farmers Liaison Council participated in the Kyushu tournament in July, aiming for a ticket for the national tournament. On October 3, 2019, the 2018 Shimabara Peninsula District Youth Farmers Liaison Council Opinion Presentation Meeting is being held in Minamishimabara City. Mr. Uchida, who belongs to the Mizuho Town Youth Agricultural Liaison Council in Unzen City, announced under the theme of “Challenge to Domestic Paprika”, has won the highest award. It is held for the purpose of presenting opinions on the improvement of agricultural management, the development of regional agriculture, and the outlook for the future, which young farmers who will be responsible for the future of peninsula agriculture are thinking about. Organized by the council and the Shimabara Promotion Bureau, about 100 people including members, related local governments, and agricultural organizations participated, and it seems that 15 representatives made announcements for each group. Mr. Uchida is a farmer who grows strawberries 40 a, paprika 2 a, etc. It was the third year since he started making paprika as a back crop of strawberries. He has felt a response and is spreading the cultivation to his colleagues. He said, “I'll take the top (No. 1) with paprika,” and it seems that the content of the announcement felt a belief in the humor. The Shimabara Promotion Bureau said, “The contents were well prepared while the farming work was busy. All of them were wonderful and difficult to attach. I hope you will continue to practice hard.” In addition, it seems that five people were selected for the Excellence Award. Six people, including Mr. Uchida, are participating in the “59th Nagasaki Agrinet Forum” scheduled to be held in February 2020. Other winners are as follows. The awards for excellence are Mr. Yamamoto (Unzen City Azuma Town Youth Farmers Liaison Council) and Mr. Shibasaki (Unzen City Kunimi Town Youth Farmers Liaison Council) and below. Going back, on January 25, 2017, the Shimabara Peninsula District Youth Farmers Liaison Council Achievement Presentation Tournament was held at the Azuma Town Furusato Kaikan. Mr. Nakano of the Kunimi Town Youth Farmers Liaison Council has won the highest award for his presentations on daily improvement of agricultural management, development and demonstration of new technologies, and efforts for regional revitalization. He and the five members of the Excellence Award participated in the “57th Nagasaki Agrinet Forum” held in Nagasaki City from February 13th to 14th. Excellence Awards are Mr. Moriuchi (Minamikushiyamacho 4H Club), Mr. Ota (Kazusa Town 4H Club), Mr. Yamaguchi (Kuchinotsu / Minamiarima Agricultural Blue Association), Mr. Honda (Aino Town Agricultural Friendship Association) Women's Club Held an opinion exchange meeting with JA officers and employees at the head office on January 18. It seems that each branch manager of the women's club, the secretariat, JA officers and employees participated and actively exchanged opinions on future activities of the women's club. It seems that the full-time officers and the departments in charge responded to various opinions and requests from the women's department, such as “enhancement of A-COOP products and point cards” and “examination of events and activity timings”. The director at that time seemed to say, “I would like to enhance the activities of the women's club through this exchange of opinions.” Gamadasu Dome (Unzendake Disaster Memorial Hall) Location, Heisei Town, Shimabara City: Japan's first experiential volcano museum “Gamadasu Dome (Unzendake Disaster Memorial Hall)” where you can experience all of the volcanoes, “Gamadasu” means do your best in the Shimabara dialect. Until the declaration of the end of the eruption in 1996, it seems that it was created to accurately pass on what happened and what remained here to posterity without fading the lessons of natural wonders and disasters. There is also a “Wonder Laboratory” where you can learn about volcanoes, science, and disaster prevention and experience a wide range of experiments, and a “Children's Geopark” where you can experience the charm of Unzen Volcano using your entire body. It was renewed in April 2018. At the indoor playset space “Children's Geopark” that can be used even on rainy days, you can play while feeling the power of the earth and the charm of Unzen volcano, such as trampoline and bouldering. There is also a space for babies and toddlers. There are plenty of attractions such as “Wonder Lab” where you can learn about science and volcanoes through experiments, and “Permanent Exhibition Zone” where you can experience and learn about the eruption of Mt. Unzen Fugen that started in 1990 using the latest technologies such as diorama mapping and drones. It seems that workshops are also held on weekends. Free of charge for the purpose of “improving the convenience of domestic and foreign tourists visiting the Shimabara Peninsula” as one of the increasingly exciting Shimabara Peninsula tourism initiatives that have been registered as a world heritage of “Hidden Christian Sites in Nagasaki and Amakusa Region”. It seems that the available public wireless LAN access service “Shimabara Peninsula Free Wi-Fi” can be used from June 1, 2019. “Shiranuhi Orange: Sumo Mandarin” : You have to give a lot of nutrition, and you need to irrigate and fertilize well when the flowers bloom and become young. Born in 1972 in Minamishimabara (Kuchinotsu Town), Nagasaki. It is famous as a fruit born by crossing “Kiyomi Orange（Citrus unshiu × sinensis）” and “Ponkan（Nakano No. 3: Citrus reticulata var poonensis (Hayata) H.H. Hu; It is cultivated in Nepal, South East Asia countries, southern China, Taiwan, and Japan. It is said to be native to the ‘Suntara’ region of India. It was first introduced in Japan in 1896 when Taiwan Governor General Mr. Sukenori Kabayama sent seedlings to Kagoshima for transplantation.）”. After ripening well on the tree, store for half a month to a month. It seems that the sourness will be removed and the sweetness will increase. Cultivation of Citrus Unshiu, which uses less water to increase sugar content, requires a slightly different cultivation method. Since around 1975, the native Shiranui Town and the surrounding area have been searching for citrus fruits to replace Amanatsu（Citrus natsudaidai); sweet form of Chinese citron. Iheard that the shipping period of medium late-ripening citrus (e.g. pomelo) is from February to the end of May. After that, it seems that it could not be shipped because it was difficult to keep it fresh. Under these circumstances, the Ehime Prefectural Agriculture, Forestry and Fisheries Research Institute Fruit Tree Research Center Mikan Research Institute and the Kumamoto Prefectural Agricultural Research Center Fruit Tree Research Institute have jointly developed a technology that can be shipped until summer with manufacturers of materials and chemicals. Use of MA packaging, a packaging technology that keeps freshness for a long time with special packaging and antibacterial preparations, minimizes respiration of fruits and vegetables, and prolongs freshness. Since fruits and vegetables are still alive and breathing after harvesting, they consume nutrients and may lose their freshness. Therefore, it seems that the film material with fine pores on the surface will be wrapped in this film material to make the air inside low oxygen and high carbon dioxide. By suppressing breathing, it slows down the aging of the skin and flesh and keeps the freshness. So to speak, it seems that mandarin oranges are in a half-hibernating state. Another technique is the application of an extract preparation of the perennial plant “Capillary wormwood; Artemisia capillaris” of the Asteraceae family. I heard that Capillary wormwood extract is safe and has been approved for use in foods, and contains ingredients with antibacterial activity. By applying this extract to the peel of medium late-ripening citrus (e.g. pomelo), it seems that the effect of suppressing rot and peel damage can be obtained. By combining these materials that help maintain freshness with the storage temperature control for each variety, it seems that summer shipments can be realized. According to the voices of the people concerned, it took nearly 10 years to jointly research with the company on the temperature to be controlled for each variety and the difference in the amount of the drug to be applied to the pericarp, and to put it into practical use. The development effort would have been immeasurable. This shipping technology began to be introduced in the market in 2012, and it seems that full-scale commercialization is progressing.

A popular citrus fruit that has a rich sweetness but has an excellent balance of sweetness and refreshing acidity, and is full of flesh. It looks rugged and hard, and it looks like it's hard to peel off, but it's easy and easy to peel off. In addition, there are few seeds and the white thin skin is soft, so you can eat it as it is, and anyway, it has a rich impression because of its chewy taste.

It has been 31 years since Unzen and Fugendake in Nagasaki Prefecture erupted for the first time in 198. It is fresh in my memory that 44 people were missing or dead in the eruption disaster. Heiseishinzan is a dome-shaped mountain formed by the eruption of about 100 million cubic meters of lava. It is said that there is a place where a rock called volcanic spine pops out like a tower and milky white water vapor spouts like MAGMA on the mountaintop.