Agricultural Improvement

投稿

2月 6, 2022の投稿を表示しています

Alzheimer's disease is thought to occur when amyloid β protein accumulates in the brain, causing damage to the cranial nerves. It is difficult to accurately measure very small concentrations, about 1/50 of the cerebrospinal fluid, and blood Aβ with conventional techniques, and amyloid β begins to accumulate in the brain about 20 years before the onset of impossibility. It seems. Therefore, it is important to notice and prevent at the stage of Mild Cognitive Impairment and Subjective Cognitive Decline. One of the causative factors of Alzheimer's disease in collaboration with the National Research and Development Corporation, Industrial Technology Research Institute, Biomedical Research Division, Brain Genetics Research Group, Hokkaido University Graduate School of Advanced Life Sciences, and Juntendo University School of Medicine, Department of Neurology. Developed a technology to visualize the dynamics of a certain amyloid β (Aβ) protein in living nerve cells and in vivo. This technology is expected to contribute to the screening of candidate substances for Alzheimer's disease therapeutic agents using cultured cells and living individuals, and to the elucidation of the onset mechanism of Alzheimer's disease. Details of this achievement were published in Scientific Reports (Sci. Rep. Nature Research) magazine (electronic version, open access) on March 16, 2016. Aβ polymerizes easily, and it further aggregates to form large aggregates. It seems that the protein (Aβ-GFP), which is a fusion of Aβ and the fluorescent protein GFP, is presumed to inhibit the fluorescence of GFP by the polymerization of Aβ. Therefore, even if it is expressed in vivo, fluorescence is not observed when Aβ is polymerized, and it seems that it has been difficult to visualize the localization and dynamics of Aβ so far. Amino acid sequence linking Aβ and GFP (human insulin: In 1953, British chemist Frederick Sanger gave the 51 amino acid sequence of insulin (a hormone required for the use of glucose, etc.), which is a hormone secreted from the bovine pancreas. Prove by determination. Start with the short-chain primer binding next to the measurement region. In the presence of four types of nucleotides, the polymerase enzyme binds the complementary nucleotides of the template DNA to the primer and extends. The intention to determine the exact DNA sequence is to stop this reaction prematurely and identify the last base at which extension has stopped, but Frederick Sanger removes the oxygen atom from the ribonucleotide to cause the extension reaction. This is called a dideoxynucleotide, and when it is taken in instead of a ribonucleotide, it seems to act to stop the elongation reaction, as if throwing a wrench into a gear to stop the movement. Polymerizer (The information of the protein written in DNA is once transcribed into mRNA and then translated into amino acids by ribosome to form a protein. RNA polymerase is used to transfer DNA to mRNA. Gene DNA is used as a template for RNA. The four nucleosides (A: adenosine, U: uridine, G: guanosine, C: citidine) that form the basis of the amino acid are polymerized to synthesize mRNA.) The enzyme will not be able to add normal nucleotides to the DNA fragment in the future. In order to stop the elongation reaction and identify what the last base is, it seems that the dideoxynucleotides are labeled with a specific color of 4 for each base so that they can be identified. In the Frederick Sanger sequence, the 3'end. By devising a reaction product of various lengths that differs by one base, which ends with dideoxynucleotide, we have developed a fusion protein that allows observation of GFP fluorescence regardless of the polymerization state of Aβ. It also appears that this fusion protein forms a highly toxic Aβ oligomer that is involved in the development of Alzheimer's disease. Diagnostic imaging methods such as PIB-PET (PET examination using PIB (Pittsburgh compound-B) as a ligand that can image amyloid accumulated in the brain) are effective, but Aβ oligomers and tau oligomers should be targeted. It seems that it is not an amyloid plaque or a neurofibrillary tangle. In addition, Alzheimer's disease is said to be the most common type of dementia, and I hear that it is more common in women than in men. In addition, while the number of patients with cerebrovascular dementia is flat, it seems that there is a tendency for it to increase. Dementia is thought to occur when the neural network of the brain is destroyed. Nerve networks consist of nerve cells exchanging information via neurotransmitters, and the junction between nerve cells where this information is exchanged is called a synapse. Impaired work seems to affect learning and memory. When not only the synaptic site but also the nerve cells themselves are damaged, causing cell death and starting to drop out, it seems that they become aware of forgetfulness (mild cognitive impairment). Eventually, when so many nerve cells are lost that the brain atrophies, it interferes with normal life and is diagnosed with dementia. In other words, many nerve cells have already died by the time dementia is diagnosed. And the dead nerve cells do not return to their original state and become the glory of the past. It is important to detect abnormalities before nerve cells begin to die and to start preventive treatment at an early stage.

- 2月 10, 2022

【Product name】 Greenhouse Citrus reticulata Siranui 【Type】 Citrus unshiu × reticulata ‘Siranui’ 【Producing area】 Fukae Town, Minamishimabara City, Nagasaki Prefecture (Zennoh Nagasaki) 【Origin of the name】 ‘Shiranui’ - Shiranuhi Town, Uki City, Kumamoto Prefecture is said to be the birthplace. It was probably named after the place name. Dekopon（Citrus reticulata Siranui）is a registered trademark owned by the Kumamoto Prefecture Fruit Agricultural Cooperative Association. Under the umbrella of the japan horticultural agricultural cooperative association: Shipped through an agricultural cooperative association with JA and citrus production. Only those who meet certain standards to maintain high quality can use the name. It was shipped through the National Federation of Citrus Agricultural Cooperatives with a sugar content of 13 degrees or more and an acidity of 1 degree or less. 【Major features】 February 1, 2022 A total of 16 land improvement districts in Minamishimabara City, Nagas...

During World War I, Britain worked with the Jewish community to raise funds for the war and implemented the Balfour Declaration. However, at the same time, in order to take advantage of Arab nationalism aiming for independence from the Ottoman Empire, the Hussein McMahon Agreement (October 24, 1915, Higher Commission for the United Kingdom in Egypt) was given to Hussein, the guardian of Mecca, instead of cooperating with the United Kingdom. Official McMahon promises to build an independent state after the end of the war in the Ottoman territory of Arabs, excluding western Syria, in five round-trip letters with Mecca's Charlief Hussein. Executed). Furthermore, it secretly concludes a Sykes-Pico Agreement with its ally, France, to divide it after the end of the war. With the end of the war and the victory of the British-French allies, Palestine and Jordan became Britain, and Lebanon and Syria became French mandates. Britain's conflicting promises to both Arabs and Jews fostered two important nationalist clashes. Although the Kingdom of Egypt gained independence in 1922, the former colonial power of Britain continued its indirect control by deploying its own soldiers for the next 25 years. Britain had substantial control, and it seems that they did not have the ability to compete with the Egyptian army at that time. During World War II, a small number of Egyptian soldiers fought on the British side, but they had little connection with the people and seemed to have very limited influence on the government. In 1947, the United Nations adopted a Palestinian division resolution to create two nations, Arab and Jewish, on Palestinian land. However, the content is to give about 43% of the land to the large number of Arabs who have lived in Palestine for a long time and about 57% to the small number of Jewish people who have newly immigrated. Happened. Britain, which ruled Palestine, unilaterally withdrew due to the intensifying conflict between Arab nationalism and Zionism, and in 1948, the Jewish side founded Israel in the midst of armed conflict and tension between Arab and Jewish. Declared. Then, the First Middle East War (1948 to 1949) broke out. In the war, 700,000 Palestinians (Arabs living in Palestine) were displaced and fled to the West Bank, Gaza Strip, and neighboring countries such as Jordan, Syria, and Lebanon. It seems that the towns and villages where the inhabitants have disappeared have been completely destroyed or Jewish inhabitants have come to live there. On the other hand, Palestinians who became refugees were forced to live in extreme distress in the poor tents and caves of refugee camps. The UN General Assembly passed Resolution 194 in December 1948, stating that refugees wishing to return to their hometowns would be allowed to return as soon as possible, and refugees who did not wish to return would be compensated for their losses. However, the Israeli side seems to have consistently denied this, saying it would lead to social and political instability. In 1950, the United Nations Relief and Works Agency for Palestinian Refugees (UNRWA) was established and began to provide basic services such as construction of simple housing, education and medical care to Palestinians. The Egyptian monarch, King Farouk, who lost the battle with Israel and decided to participate in the war, lost his authority, and the Egyptian army accused the king of the responsibility for the defeat. In 1952, the Free Officers Movement led by Gamal Abdel Nasser forced a coup d'etat. The overthrow of the royal system by the military (later the Egyptian revolution) formed the basis of modern Egyptian republicanism. After the coup d'etat, under the command of Gamal Abdel Nasser, who gained popular support for his strong charisma, he proceeded with modernization with the aim of becoming a powerful army. During the North Yemen Civil War (1962-1970), the military dispatched expeditionary forces to Yemen to support the Yemen Arab Republic government forces. Pay a lot of costs. Later, the Six-Day War broke out between the Arab countries and Israel. Gamal Abdel Nasser, who commanded the Allied Forces, suffered a catastrophic defeat by the Israeli army and was robbed of the Sinai Peninsula, which was under Egyptian control. It seems that the credibility of the military has fallen to the ground due to a series of failures. 1970 Gamal Abdel Nasser (2nd President of the Republic of Egypt. With pan-Arabism and pan-Africanism, he founded the United Arab Republic consisting of Egypt and Syria and became its first president, and became the second president of the African Unification Organization. (Chairman also served) After his death, coup d'etat Anwar al-Sadart will take over. He first took office as Vice President, purged Nasser factions, changed political and economic policies, and worked on the reorganization of the Egyptian army, which had been exhausted by the Six-Day War. In October 1973, he led the army in the Yom Kippur War, aiming to recapture the Sinai Peninsula. Three weeks later, it ended with Israel's dominance, but the Egyptian army had great results at the beginning of the war. In 1978, the Sinai Peninsula was returned to Egypt following the Camp David Accords between Sardat, Israeli Prime Minister Menachem Begin, and US President Jimmy Carter. With this achievement, the undefeated myth of Israel has collapsed, and the Egyptian army seems to have regained trust as an army with the power to protect national interests. After the assassination of Sardat in 1981, former Air Force General Mubarak became president. From around this time, the military promoted modernization with the support of the United States and expanded its military power. As Mubarak pushed for economic liberalization in the 1990s, he began to seek dividends that exceeded US military support from a shortcut to capitalism. In Egypt, military-owned public-private joint ventures seem to account for 15-20% of GDP. In addition, military personnel are guaranteed hospitality based on their powerful capital strength. As the military's economic power permeated society as a whole, it seems that its influence on civil society also increased. A long time later, on the night of May 20, 2021 last year, the Israeli Prime Minister's Office held a security cabinet meeting on the same day, based on the recommendations of the Israeli Army Chief of Staff, Secretary of State Simbeto, Secretary of Mossad, and Chairman of the National Security Council. Announced unanimous approval of the Israeli Gaza militants to accept the Egyptian mediation proposal to unconditionally stop the war. It was announced that the ceasefire would start at 2:00 am local time on the 21st. Regarding Japan's support for Egypt, which is the focus of attention, the dream of establishing a university in Egypt that could serve as a core research and education center in the Middle East and the Arab world is called the Egypt-Japan University of Science and Technology Initiative, and in January 2009, the two countries I have a general agreement. Until now, universities in Egypt could be enrolled free of charge if they had a certain level of academic ability, as it was meant to prevent unemployment among young people, but the level of education is declining year by year, with 84 students per teacher. It seems that he was doing it. In addition, it seems that the Faculty of Engineering was in a situation where it was not possible to carry out experiments and practical skills from beginning to end with classroom lectures. For this reason, the Egypt-Japan University of Science and Technology seems to focus on practical skills and research by a small number of elites, collect tuition fees, and accept foreign teachers and international students. With JICA playing a central role, we were aiming to open the school in the fall of 2009 while soliciting support from Japanese universities, creating a curriculum, building an operating system, dispatching core faculty members, and preparing equipment. Study abroad from neighboring Arab countries is also expected, and Japan plans to continue to provide support based on its own experience and technological capabilities to Egypt, which wants to further strengthen science and technology in the future. Established in 2010, it is located in New Borg El Arab City, Alexandria Governorate, Alexandria Governorate, Egypt. High-quality research at the National al-gāmaaʿa al-almāsreya al-alyābaneya lel ʿoloom wal toknologya (E-JUST (Hod Sakrah WA Abu Hamad, Borg Al Arab Al Gadida City, Alexandria Governorate: Egypt - Japan University of Science and Technology) / Through the practice of education, the formation of a multi-layered network with related organizations in Japan and overseas, and appropriate university management, the school aims to be established as a top-level research university in Egypt. Through these activities, Industrial and science and technology human resources produced by E-JUST will contribute to the overall development of the higher education sector and industry in the Middle East and Africa in the future.

- 2月 08, 2022

【Product Name】 Andes melon 【Type】 Cucumis melo L. 【Within the production area jurisdiction】 The location of the head office is in Minamikumamoto, Chuo Ward, Kumamoto City, Kumamoto Prefecture, excluding former Kamoto District Ueki Town, former Shimomashiki District Jonan Town and Tomiai Town (JA Kumamoto City, Kumamoto Prefecture Economic and Agricultural Cooperative Association). 【Derived from the name】 Distribution is safe to sell, Safe for consumers to buy, these are possible varieties : I heard that I abbreviated “that's a relief.” 【Major features】 Judging from the ruins found in various parts of Kumamoto prefecture, it is estimated that people have lived in this area for about 15,000 years. After that, the remains of the Jomon period from about 7,000 BC to about the 2nd century BC seem to have been found in about 800 places in the prefecture such as the river basin of the Ariake Sea and the Shiranui Sea and Amakusa Island. In the 2nd and 3rd centuries BC, Yayoi's ...

Unable to deal with infrastructure, not bad money, once there are 6 times, 7 times. Suggests danger to brain fog, lungs (mediastinum). Still equivalent to class 2: mutant virus Omicron. Neo Omicron: Neo Cov discovered as a high-risk corona variant in South Africa: Invades bat lung cells using the ACE2 receptor in human cells. Like SARS-CoV-2, which causes COVID-19, it seems to invade human lungs. The new coronavirus and SARS coronavirus are known to invade cells by utilizing the ACE2 receptor in the human body. During this invasion, it seems that the flexible protrusions of the spike protein that make up the coronavirus crown: spherical shape with a diameter of about 100 nm torque and protrusions on the surface. Morphology are bound to the ACE2 receptor. Neo Cov binds to the ACE2 receptor in a different way than the COVID-19 pathogen. Neither antibodies nor protein molecules are effective against this variant, so it seems that Neo Cov could Be particularly dangerous to humankind. Accelerating illness by inciting Cov (parable to further accelerate the progression of epidemic illness) Decline of economy (national interest) (Is it better to abandon the idea of proud Japanese people? Rage） * There is no public hygiene. Man-made dominoes: Man-made disasters (throwing rounds, not protecting the people, not taking responsibility, opportunism) ≒ students, local governments, health centers, medical care (in the limelight), economy, family (relatives, friends) collapse and unlucky state. Effective Reproduction number: Re-recognition of Rt! No fragments of rationality. Class 2 infectious diseases [Law] Acute gray myelitis, tuberculosis, diphtheria, [Severe acute respiratory syndrome (pathogen is coronavirus SARS coronavirus genus) (Limited)], Middle East respiratory syndrome (limited to those whose pathogen is beta coronavirus MERS coronavirus), bird influenza (H5N1, H7N9) * [Severe acute respiratory syndrome (pathogen is coronavirus SARS coronavirus genus) (Limited to)] Class 5 infectious diseases [Law] Infectious diseases (excluding infectious diseases such as bird influenza and new influenza), viral hepatitis (excluding hepatitis E and hepatitis A), cryptosporidium disease, acquired immunodeficiency syndrome, Genital chlamydia infection, syphilis, hemp, methicillin-resistant yellow staphylococcal infection [Ministry Ordinance] Amoeba diarrhea, RS virus infection, pharyngeal conjunctival fever, group A hemolytic Lensacytic pharyngitis, carbapenem-resistant enterobacterial bacterial infection, Acute flaccid palsy (excluding acute gray leukomyelitis), infectious gastroenteritis, acute hemorrhagic conjunctivitis, acute encephalitis (Westnile encephalitis, western horse encephalitis, tick-mediated encephalitis, eastern horse encephalitis, Japanese encephalitis, Venezuelan encephalitis and Caused by Rift Valley fever), Chlamydia pneumonia (excluding parrot disease), Kreuzfeld-Jakob disease, fulminant hemolytic Lensa ball infection, bacterial meningitis (menelitis, pneumonia, influenza) (Except when identified as), dialdiosis, invasive influenza infection, invasive domino infection, invasive pneumococcal infection, varicella, genital herpesvirus infection, apex condyloma, congenital wind shin Syndrome, limb disease, infectious erythema, idiopathic epilepsy, disseminated cryptococcosis, tetanus, bancomycin-resistant yellow staphylococcal infection, bancomycin-resistant enterococcal infection, pertussis, wind rash, penicillin-resistant pneumococcal infection, herpangina, Mycoplasma pneumonia, aseptic meningitis, drug-resistant Ashinetobacter infection, drug-resistant purpura infection, epidemic keratoconjunctivitis, epidemic parotid glanditis, gonococcal infection * Infectious diseases such as new influenza, new coronavirus infection (The pathogen is beta coronavirus coronavirus (Chinese in January 2020) Limited to those newly reported by the Republic of China to the World Health Organization that they have the ability to transmit to humans. ). ) Pay that does not touch during the period from the emergency of October to December 2021 to normal times (officials, special civil servants, Article 147, self-employed executive body, as referred to in Article 73 of the Constitution of Japan, Local civil servants in special services to which the Local Civil Service Law does not apply) Like us, if it is privately owned, it will be dismissed or retired. Around 1918-1920, H1N1 subtype: 1918 flu pandemic, Spanish flu Innocent children of the Taisho era, from Anraku Jodo to Anno Scream (In 1936, signed a Japan-Germany Anti-Comintern Pact with Germany, The following year, in 1937, the Roh Mizobashi incident (fired from the Chinese side) triggered the war between Japan and China to 1941 (December) US war ~ 1945 ~) The former Soviet Union (occupies eastern Poland based on the secret protocol of the German-Soviet Anti-Comintern Pact, Estonia, Latvia, Lithuania's Baltic three countries are also forced to occupy, and a war is also launched against Finland) started the war against Japan on August 9, 1945, September 8, 1951 (Spanish flu treaty: Treaty of) Peace with Japan: 1952 Convention No. 5)

- 2月 08, 2022

【Product Name】 REIKOU（Kagami Citrus）【Type】 Citrus L. 【Wholesale land】 Hada, Karatsu City, Saga Prefecture (KAGAMI Fruit Agricultural Cooperative, JA Group Saga) 【Origin of the name】 It's a little reddish, bright orange, and is said to have been named for the precocious oranges that have been around since the Lunar New Year. 【Major features】 The new variety “Reikou” is desired to cultivate citrus varieties that mature after the beginning of the year in order to improve the varieties of citrus fruits in Japan, which are biased toward the production of Satsuma mandarin that matures within the year. It is a variety made for the purpose of peeling citrus varieties with high sugar content and good taste. It is loved as a tangor of Nakate, which was bred by crossing “Kiyomi oranges / Angkor No. 5 oranges” with “Murcott oranges”, but its appearance is red-orange, smooth and beautiful. It has aroma, high sugar content and good taste. Male sterility (In the “cytoplasmic-only type” in which ...